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You don't lose the game for having 0 or less life. As long as you have 0 or less life, all damage is dealt to you as though its source had infect....

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

({R/P} can be paid with either {R} or 2 life.) Gut Shot deals 1 damage to any target.

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, each opponent loses 3 life, then you gain life eq...

({T}: Add {B}.)

{X}{B/P}: Remove up to X counters from target permanent. For each counter removed this way, Hex Parasite gets +1/+0 until end of turn. ({B/P} can b...

Target player draws three cards, loses 3 life, and gets three poison counters.

Creatures entering the battlefield don't cause abilities to trigger.

Whenever an opponent loses life, that player mills that many cards. (Damage dealt by sources without infect causes loss of life.)

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, create a 1/1 red Goblin creature token with haste...

Flash At the beginning of your end step, draw seven cards. Each opponent's maximum hand size is reduced by seven.

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, each opponent loses 3 life, then you gain life eq...

Until end of turn, creatures you control get +1/+1 and gain trample and infect. (Creatures with infect deal damage to creatures in the form of -1/-...

When Inquisitor Exarch enters the battlefield, choose one — • You gain 2 life. • Target opponent loses 2 life.

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Enchant creature At the beginning of your upkeep, enchanted creature's controller sacrifices it and you create a 1/1 colorless Phyrexian Myr artif...

First strike Metalcraft — Creatures you control get +3/+0 as long as you control three or more artifacts.

Flying Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.) {3}{U}: Prolif...

Untap all artifacts you control during each other player's untap step.

({R/P} can be paid with either {R} or 2 life.) Gut Shot deals 1 damage to any target.

Permanents enter the battlefield tapped this turn. Draw a card.

Trample Whenever a source deals damage to Phyrexian Obliterator, that source's controller sacrifices that many permanents.

Flying Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)